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Evaluation of 1,401 patients receiving taxane-based therapy from 23 phase II or III trials demonstrating increased risk for CIPN development with paclitaxel compared with docetaxel, in participants receiving combination therapy with both taxanes and platinum agents, and in patients with increased age or a history of diabetes

These side effects may go away during treatment as your body adjusts to the medicine

Berger RCM, Benetti A, Girardi ACC, Forechi L, de Oliveira RM, Vassallo PF, et al

& Amini, Z

During terminal differentiation, mature white adipocytes utilize cell death-inducing DNA fragmentation factor 45-like effector (CIDE) family proteins (particularly CIDEC) to mediate the fusion of small lipid droplets, ultimately forming a unilocular central lipid droplet that occupies over 90% of the cytoplasmic volume

Baillieres Clin